Patients with low ovarian reserve - who we know in advance will have a poor response to IVF medication - are a very challenging group of patients. There is no point of increased medication doses as it doesn’t offer any advantage. For this reason, Duo Stim (double stimulation) was developed. Duo Stim is a new approach that seems to increase the success rate to women with low ovarian reserve. It includes two egg retrievals in the same cycle.