The "Ideal" Ovarian Stimulation
According to Mr. Evripidis Mantoudis, to achieve the “ideal” ovarian stimulation, we focus on the following issues:
• Meticulous monitoring of the cycle via ultrasonograms and hormone level controls.
• Adjustment of dosage depending on the course of the cycle.
• Availability for oocyte retrieval seven days a week, so as to select the optimal moment for it.
Of equally high importance though is our approach to medication. Contrary to the “more drugs = more oocytes = more chances of achieving pregnancy” rationale, in the past few years, at “gennima”, Mr. Evripidis Mantoudis uses lower medication doses, with excellent pregnancy achievement rates and without the risk of ovarian hyperstimulation.
Based on his personal clinical experience, patients who produce many oocytes (more than 16-20) during the ovarian stimulation phase, finally have lower fertilisation rates, as well as lower top quality embryo rates. Moreover, the endometrium is less receptive to embryonic implantation, due to high estrogen concentration. This observation has been scientifically confirmed by a recent clinical study, which took place in University Gynaecology Clinics of the Netherlands and has been published in the international scientific magazine “Human Reproduction”. The study showed that embryos from IVF cycles, which have yielded many oocytes have more chromosomal abnormalities (genetic material disorders). This has been documented with preimplantation genetic diagnosis, a specialised technique that screens the embryo for possible genetic material problems before embryo transfer.
Lower doses of medication yield fewer oocytes (6-10), which have though higher fertilisation rates and give better quality embryos (better pregnancy potential). Moreover, the endometrium is more receptive. Besides optimal results, less medication guarantees a satisfaction rate of almost 100%, because “disturbance” in the woman’s system is the least possible. Thus, the whole procedure becomes easier, more comfortable and has no complications.
Please read below the relevant article of Mr. Evripidis Mantoudis, published in the newspaper Weekend Xpress (May 18, 2010):